Messier 106 also known as NGC 4258 is an intermediate spiral galaxy in the constellation Canes Venatici. It was discovered by Pierre Méchain in 1781. M106 is at a distance of about 22 to 25 million light-years away from Earth. M106 contains an active nucleus classified as a Type 2 Seyfert, and the presence of a central supermassive black hole has been demonstrated from radio-wavelength observations of the rotation of a disk of molecular gas orbiting within the inner light-year around the black hole.  NGC 4217 is a possible companion galaxy of Messier 106.  A Type II supernova was observed in M106 in May 2014.

It is one of the largest and brightest nearby galaxies, similar in size and luminosity to the Andromeda Galaxy.  The supermassive black hole at the core has a mass of (3.9±0.1)×107 M☉.

M106 has also played an important role in calibrating the cosmic distance ladder. Before, Cepheid variables from other galaxies could not be used to measure distances since they cover ranges of metallicities different from the Milky Way's. M106 contains Cepheid variables similar to both the metallicities of the Milky Way and other galaxies' Cepheids. By measuring the distance of the Cepheids with metallicities similar to our galaxy, astronomers are able to recalibrate the other Cepheids with different metallicities, a key fundamental step in improving quantification of distances to other galaxies in the universe.

This final image is heavily cropped from the original due to the small size of the target in the FoV of my Esprit 100ED.  The integration time is only around 4.75 hrs; with the small target size and relative dimness, it would benefit from some increased data.

ZWO ASI2600MC-P w/Lextreme filter 180x89 exposures.  Gain 100, offset 50, temp -10dgc, mount Software Bisque MyT
Stacked and processed in PixInsight, final touch up  and noise reduction to the jpeg in Photoshop w/Topaz AI DeNoise.

Update: Revision B
I went back and reprocessed as I was not satisfied with the color tint of the original.  I had used the arcsinstretch function in PixInsight to stretch the image in the first attempt.  While it worked on stretching the image, it also added a very heavy red saturation to all the objects which required some significant tweaking to get out.  The result was some very off colors to the stars.  In revision B, I went back to the 'standard' histogram based stretch technique which helped retain a more accurate rendition of the star colors.

Update: Revision C and D (Final)
I wasn't happy with the red color cast created by the 'new' PixInsight technique I was trying out.  So I went back and started from scratch, and used my more 'tried and true' processing approach which generally is more minimalistic.  I think the denoising and color control turned out better both in the 'full' image (Rev C) and in the cropped image that puts M106 as the primary component.