The Rosette Nebula, C50, is an H II region located near one end of a giant molecular cloud in the Monoceros region of the Milky Way Galaxy. The open cluster NGC 2244 is closely associated with the nebulosity, the stars of the cluster having been formed from the nebula's matter. 

The Rosette Nebula is a cloud of dust containing enough gas and dust to make about 10,000 stars like our Sun. In the core of the nebula, just left of center in this image, is a cluster of hot, bright young stars. These are warming up the surrounding OIII gas and dust, illumnating in a blue hue among the thick dark lanes providing a bit of structure..

The Rosette is a very busy area!  A survey of the nebula with the Chandra X-ray Observatory has revealed the presence of numerous new-born stars inside optical Rosette Nebula and studded within a dense molecular cloud. Altogether, approximately 2500 young stars lie in this star-forming complex, including the massive O-type stars HD 46223 and HD 46150, which are primarily responsible for blowing the ionized bubble. Most of the ongoing star-formation activity is occurring in the dense molecular cloud to the south east of the bubble.

Another interesting tidbit of knowledge - On April 16, 2019 the Oklahoma Legislature passed HB1292 making the Rosette Nebula the official state astronomical object. Oklahoma Governor Kevin Stitt signed it into law April 22, 2019.

This photograph is comprised of 253 images totaling ~12.5 hours of exposure taken in Nov 2022 with a ZWO ASI2600MC Pro camera and a Skywatcher Esprit 120ED telescope  riding a Skywatcher EQ6r Pro equitorial mount from my driveway in the hills of western NC. Image acquisition with APT & PHD2. Processed manually in PixInsight with PS doing the jpeg conversion.

There are 2 Caldwell designations as well as 5 New General Catalog (NGC) items within this cluster.  They can be read about in Wikipedia via a google search.

Cheers!